When you're in the bathroomtrying so hard to take a shit that when you come out, you feel like its 20 years later
"Where have you been man?"
"I've been in the bathroom for the last two hours. What time is it? I thought the sun already set."
"It's only been 15 minutes. You had a shit van winkle"
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.