Rene Dif Share definition Flag A clear odorous liquid that leaks out of the anus when masturbating. The stench of rene dif dripping from my boyfriend's ass after I gave him a handjob was vomit inducing. Rene Dif by Happy Klaus April 19, 2011 0 0 Get merch Get the Rene Dif mug. Buy Now — $32.95 See more merch