Shit that real niggaz do, such as sellin' drugs, killin' other niggaz, fuckin' bitches and then neglectin' his kids, goin' to buy milk and never comin' back, smokin' weed, or eatin' a lot of chicken.
Alternative meaning: shit that comes out of a real nigga's intestine.
Used after someone does something which they think is great they may say "it's that real nigga shit". This word was created by Josh Tetteh after he got a fresh trim.
In a tabletop game, a murderhobo is a player who murders NPCs indiscriminately. This is normally derogatory, referring to a player who totally ignores quests, dialog, backstory, trade, world building etc.
The term is most common with Dungeons and Dragons, but it can be applied to most RPGs where the player is allowed to kill most quest-giving NPCs and NPC traders. E.g. Elder Scrolls, Fallout, Divinity original sin.
DM: The sad little orphan girl tugs at Steve's trenchcoat to get his attention, and ask for help saving her pet dog from...
Steve: I'd like to roll a strength check against strangling the orphan.
Dave: I call dibs on the dog.
DM: You murderhobos disgust me.