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Short form for Quiet The Fuck Down. Something you say to kids who talk a lot who wont shut up.
(Bunch of kids shouting for no reason and wont calm down)
You: QUIET THE FUCK DOWN! Dumb bitches

or online to a bunch of spammers
You: QTFD Fucking Spammers!
by I.Am.No.One. June 22, 2010
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