Meaning filled with angst, or of/relating to Edgar Allen Poe, this word originated with art school dorks and eventually made it's way to inner city street gangs.
"Bro, that mothafucka is Poe'd up! Look at his eyeliner!"
"He ain't Poe'd up, mein! He's just a fag!"
The act of inserting a turkey baster filled with Pellegrino water up the ass of an unsuspecting girl during intercourse and discharging the baster hopefully causing simultaneous orgasm. For a similar result, see donkey punch.