OMSF 

Oh My Sweet Fez - Exclamation of your love for someone who is weird or acts strange

"OMSF, you're crazy."

OMSF by SweetFez June 29, 2008

OMSF 

Oh my secular figurehead! An atheistic alternative to OMG.

OMSF! PONIEZ!!!

OMSF by st1977 September 1, 2011

OMSF!

Oh My Shitting Fuck!

Variation on OMFG, for when some crazy shit surprises you.

Eg 1, OMSF! Did you see the size of that bird, it could of taken our baby

Eg 2, There's only one acronym to describe my feelings right now and that is OMSF!!!

OMSF! by j# May 15, 2010