One of English alternative rock band Radiohead's two guitarists, the other being Jonny Greenwood. Ed is known for his extensive pedal usage, which is instrumental in creating the atmospheric textures found in many of Radiohead's songs. He actually runs two pedalboards, one for delay/atmospheric sounds (most prevalently heard during the Kid A era) and one for distortion and other more straightforward effects (think The Bends and OK Computer). He is by far the tallest member of Radiohead at 6'5'', as well as considered the most attractive member. He has handled a considerable amount of press in the past for the band, probably second to Thom and possibly Colin. O'Brien was the first Radiohead member to move away from the bands hometown of Oxford to London, circa In Rainbows. He has a wife, Susan, a son, Salvador, and a daughter, Oona, and has been ranked by several lists and polls as one of the greatest guitarists of the modern era (including Rolling Stone's Top 100 Guitarists, sharing spots 59 and 60 with Jonny).
New Radiohead listener: How does the tall guy on the left get his notes to sustain for so long?
Pretentious Radiohead fan/gear whore: Ed O'Brien? Most all of his guitars are outfitted with Fernandez Sustainers, which he then routs through a shitton of delays to sound like a fucking siren.
by captain_e August 12, 2011
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THe funniest host ever if your drunk high, sober or clean, it doesn't matter with conan. beats the sh1t outta letterman and leno, even with worse guest because of his timeslot.
by tim pitts March 11, 2004
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The fucking sexiest and cutest man alive. He played roles in Teen Wolf, The Intership and The Maze Runner. He also has the greatest and cutest smile and moles, a really nice booty and hands.
A: Hey ,do you know Dylan O'Brien?
B: Oh, you mean Dylan, my future husband and the cutest smol bean in the entire world?
by 3urrit0 July 23, 2017
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Timmy after he takes a shit in his hands and tries to throw it into a toilet as if it were a basketball but he misses and starts crying.
CRIEN' O'BRIEN LIKES $5 FOOTLONGS WITH LOTS AND LOTS AND LOTS AND LOTS AND LOTS OF MAYONAISE.

also see gigalo.
by Grant (Davis) Goldfarb Cheever January 26, 2009
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Jamie obrien is a slur you can call someone if they are either... a simp, watches 'how to become alpha male' videos, treats women like gods, theyre self worth is extremley low, threathens to rape women, threatens to kill himself or tells people to kill themselves.
"Woah did that guy just say he would suck lily murphys vagina??"
"Damn that guys is a total JAMIE O'BRIEN"
by Egg1273 June 17, 2022
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The host of Late Night with Conan O'Brien on NBC. In my opinon, funnier than Leno, Letterman, Kilborn and (unfortunatley) Kimmel. Though he rarely receives A-list celebrities, his skits and antics are second to none in hilarity. His show spawned the infamous character of Triumph the Insult Comic Dog.
Staying up for Conan O'Brien is worth while, even though it usually starts late because of stupid Jay Leno.
by Mark August 18, 2004
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