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No issac

another way to say no homo. saying come a neighborhood in Love Field.
Did you just touch my ass?”
“No issac.”
Oh shit you good.”
by dallasxrevenge September 12, 2019
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Issa no 4 me

When you reject something--commonly said by a female or someone of female character-- because you find something offensively ugly, you just want to respond w/ a sassy no, or something offensive in general.
Also sometimes sided with a teacher eating gesture-- curling your pointer finger in front of your mouth while giving the look-- to add exaggeration to the rejection of an irk
____: bro Ryuk from Death Note is like so hot. I mean the eyes, the hair, the bod--

Me: issa no 4 me. He is not attractive sry not sry.
by Anonymous#518819738 September 4, 2022
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