Muletoe Share definition Flag A cameltoe of the ass, where the pants are so high up and tight, it separates the cheeks into two distinct hemispheres. Did you see Derek's pants, he is showing some serious muletoe? Muletoe by EthanTremblay June 7, 2011 0 0 Get merch Get the Muletoe mug. Buy Now — $32.95 See more merch