1. The grasping of hands by two people, as in greeting or leave-taking.
2. Computer Science. An exchange of signals between two devices when communications begin in order to ensure synchronization.
by Anonymous March 19, 2003
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"Honey, don't be mad! It was just a handshake!"
by me June 1, 2004
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march 19th is national handshaking day.

or

have you had your handshake today?
by Billy Bichititimen January 28, 2005
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Sir Thomas, mounted on his black stallion, gave a handshake to Sir Jamal as they passed one another on the street. "Wut up dawg," responded Sir Jamal.
by Butzo November 16, 2006
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I'd loan you my car for the weekend, but I know you hate to drive a handshaker.
by ChristianRory December 24, 2005
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