homo Share definition Flag 1. prefix: from the greek homos, it means "the same". From the Latin homo, it means "man" 2. A derogatory term for a gay man. 1. homogenous: the same. Homo erectus: standing man. 2. Todd wore K-Mart jeans today! What a homo! homo by Militant Liberal May 2, 2005 Get the homo mug.Get the mug. Buy Now — $25