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The name of a straight Methamphetamine shot meant to shoot up intravenously or rectaly. The word is used primarily to speak in public.
Ex bf: Hey hook me up a gizmachi and I’ll make you a gizmachi too, for old times sake!

Ex gf: James I don’t fucking tweak it no more get out of my face fool
by MellowKitten November 06, 2018
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