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Abbreviation for "For Flying Fuck's Sake". This is much more serious than the regular "For Fuck's Sake" and shouldn't be taken lightly.
Joe: "For Flying fuck's sake, Carl! Come here."
Carl: (Thinking to himself) "Yep, I'm fucked."

In text chat:
Jeanna: John, I just found out at the doctor that I'm pregnant
John: FFFS, Jeanna, we used two condoms!
FFFS by SpodermanUnlimited November 4, 2016
Related Words
Fuckin' Fickle Faggot Syndrome.

A person, (gay or not) who tends to be fickle or flake out on any or all commitments. Usually the the infected person thinks only about themselves and could care less about his/her surroundings.
I certainly wouldn't make plans with John. He has a fatal case of FFFS.
FFFS by oraqle October 9, 2008
Progetto per la socializzazione, e il supporto a individui con nuove forme di depressione
lo FFFS di ieri è stato utile dai
FFFS by Leila8888 October 21, 2018
hi lol i broke my phone again im on my laptop

fffs again????
fffs by maceythecat_ October 18, 2020
FFFS means 'for fucking fucks sake', it is a more aggressive and frustrated way to say 'for fucks sake'.
SapNap: hey George what does-
George: FFFS SAPNAP SHUT THE FUCK UP
Fffs by Lavender-town January 14, 2021