When one (normally a Twitard or Twihard) becomes extremely obsessed with Edward Cullen from Twilight.
Twitard: OMG I LUV EDWARD!!!111 HES SO HAWT!!11111
Me: Another victim of Edward Cullen Disease passes by...
Me: Another victim of Edward Cullen Disease passes by...
by I spend too much time here April 6, 2013
Get the Edward Cullen Diseasemug.