E.D. squared Share definition Flag E. D. squared is when your Explosive Diarrhea causes you to also have Erectile Dysfunction. Hey Chickenbag and Jerrycurl, my Explosive Diarrhea is so bad I can't get a hard on. I have E.D. squared. E.D. squared by SJL123 August 13, 2020 0 0 Get merch Get the E.D. squared mug. Buy Now — $32.95 See more merch