A retard's (or an old fart's) way of referring to being under the influence of cocaine.
Grandpa: Tommy, why don't you come over tomorrow night so you can get coked up with your favorite granddaddy
Tommy: *sigh* Grandpa, that's not how you say it. Plus you shouldn't be doing cocaine, you're like practically dead
12 step recovery jargon referring to someone new who talks about how great life is, now that they'resober. Usually meaning that the person is out of touch with reality.
The new guy seems pretty happy for a dude who has no job, no money and no family. He must be on a pink cloud.