A massive fart released from the anus that may cause nauseousness.
Chad ripped a Big One in Kiersten's face while she was giving him his morning blow!
by SlopNChop November 26, 2016
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A devastating Earthquake that strikes the San Andreas fault line about every 100 years, last happening hitting in The 1906 San Francisco Earthquake. Most commonly used in reference to a predicted future earthquake.
I think we should invest in some sturdier infrastructure here. I mean, what about when the Big One hits?
by 54229 265546437 April 21, 2018
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"The Big One" is used to describe a big person in a small place that is accused of everything . Commonly associated with Avichay as a "Big One". Originally: "Shiur Anglit"
The big one constantly knocks into people with his immense size.

"Hey you, the big one. "
by Cool Bamb May 20, 2016
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Something big and typical. (Aka gun, score or anything you could describe)
Lester : "The big one!"
Michael : "The big one!"
Trevor : "The big one!"

Franklin : "What the fuck is the big one?"
by Sosku10 August 21, 2020
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What one bites when one dies.
That dude is totally dead, he bit the big one.
by jcoffland May 10, 2010
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A phrase used in NASCAR to describe a large crash at Daytona, or Talledega involving several cars. Usually caused by the restrictor plates on the cars keeping them bunched together, 3 or 4 across, 43 deep, untill one car in the front cuts down in front of another car to close, and spins out in front of the rest of the pack. The Big One usually has 5-10 cars involved but some have had up to 26.
Just look up "The Big One @ Daytona" and you will get a pretty good idea.
by Gamewizard September 30, 2009
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