A massive fart released from the anus that may cause nauseousness.
Chad ripped a Big One in Kiersten's face while she was giving him his morning blow!
by SlopNChop November 26, 2016
Get the Big One mug.
A devastating Earthquake that strikes the San Andreas fault line about every 100 years, last happening hitting in The 1906 San Francisco Earthquake. Most commonly used in reference to a predicted future earthquake.
I think we should invest in some sturdier infrastructure here. I mean, what about when the Big One hits?
by 54229 265546437 April 21, 2018
Get the Big One mug.
An extremely large bomb, often nuclear.
During the Cold War the United States was afraid that the Soviets would drop the big one.
by blenheimears April 14, 2009
Get the big one mug.
"The Big One" is used to describe a big person in a small place that is accused of everything . Commonly associated with Avichay as a "Big One". Originally: "Shiur Anglit"
The big one constantly knocks into people with his immense size.

"Hey you, the big one. "
by Cool Bamb May 20, 2016
Get the The Big One mug.
Something big and typical. (Aka gun, score or anything you could describe)
Lester : "The big one!"
Michael : "The big one!"
Trevor : "The big one!"

Franklin : "What the fuck is the big one?"
by Sosku10 August 21, 2020
Get the The big one mug.