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1. A person who is so ugly they might as well have just experienced being hit 5 times in a row, like in Street Fighter.

2. A different way to say shit. When 5 hit combo is displayed in a game, it looks like it says the word shit.
1. (Seeing a really ugly girl:) "5 Hit Combo, man."

2. "She said don't come near her again, man."
"Oh, 5 Hit Combo."
by Dan In The World April 05, 2006
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