Depression 

A clinical condition caused by an imbalance in the levels of Serotonin in the brain.
Serotonin is a neurotransmitter in the brain which is responsible for feelings of wellbeing and contentment. A decline in the level of Serotonin present in the brain causes severe feelings of anxiousness, lethargy, tiredness and a prolonged sadness.

Depression is a lasting condition, and is not to be confused with being an emo wanker who sits around slashing up for attention.

Emos are milking the whole depression card. They're ruining the seriousness of the issue, much like they ruined checkers, skating and punk music.
If you know of somebody that is legitimately depressed, tell them to seek medical help.

Depression by I.defeated.the.system October 8, 2008

Depression 

Often confused with sadness.

Depression is extreme sadness prolonged over an abnormal period of time. You lose interest in the things you used to enjoy participating in, and detach yourself from the ones you love.

Sadness is momentarily being upset or effected by something.

John used to love hanging out with his friends and playing baseball, but ever since his mother passed away, he sank into a depression and didn't enjoy these things anymore.

Depression by anonymousme123 September 7, 2012

postcardigan depression 

when you take off your cardigan then get depressed

Julie hasn't left her house since the party. I think she is suffering from postcardigan depression.

postcardigan depression by squatsandmilk August 7, 2011

Post-TDK Depression 

After watching The Dark Knight, you settle into a depression because of the realization that no movie will ever be as good again.

Man, I was watching Tropic Thunder the other day and it was kinda funny, but The Dark Knight was a million times better. I'm just gonna go watch it on IMAX so I can beat this Post-TDK Depression.

Post-TDK Depression by JambaJews December 23, 2008

Depression Dots 

Dots used to represent long dramatic pauses in phrases to show how depressed a person is, the more dots a person uses, the more likely they are to kill you...and your family

gone......and nobody cares.........

Depression Dots by Buddy lee October 13, 2003

e-depression 

The mental disorder that 95% of myspace users suffer from.

"Oh help, my life is so shit, i wanna die, im suffering from e-depression"

"He was my life, i cant live without him"

"Somebody kill me, i hate life"

e-depression by Zolace September 15, 2008

Post Holiday Depression 

Post Holiday Depression (PHD) : General feeling of sadness and depression and hatred of all things work-related soon after a long holiday. Symptoms usually show at least 4 hours into the first work day after a holiday and can linger for up to a year until the next festive season.

No known deaths have have recorded due to PHD, but severe cases of office in-fighting, bickering, and crying have been noted in the IT industry soon after New Years.

Sue came back from the Cape Town with a severe case of Post Holiday Depression and refuses to send those invoices!

Post Holiday Depression by Dr I. H. Work January 26, 2010