The breakdown to this is the expressor to the expressee: shizzle my nizzo! This means putting action upon any object. Shizzle is the verb and Nizzo is the object of the verb. The expressor is asking the expressee to "do something to something"! Whatever it is and to what is up for purely speculative interpretation and depends on the linguistic conditions and the situational environment of the moment.
Lord girlfriend, I haven't seen you for so long. Come over here and "shizzle my nizzo"!
by Merrily McCarthy September 15, 2003
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means "for sure my brother" or "for sure my friend"
When asked if the party was good...
"fo shizzle my nizzo!"
by Kristy September 16, 2003
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Generally means that the person saying it, is a twat
Hey! fo shizzle my nizzo biotch mo fo uhhmmmmmmmm. sup girlfriend?
by pea fan September 15, 2003
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the wanna-be attempt of 'fo shizzle mah nizzle,' usually said by some white wanna-be.
"You wanna go to the bar?"

"Fo shizzle my nizzo"

"fuckin wigga"
by FaT J September 13, 2003
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