From the word whore; how the word sounds when used by people who have trouble with the letter R at the end of a word (examples: sure, "sho"; more, "mo"; for, "fo").
"That girl is such a ho."
"If you're going to use sexistnames, could you at least pronounce them correctly?"
Jess is the biggest fucking ho i've ever met. She was going out with Mike for about 10 minutes before she got fingered by Jay and Rick (at the same time)