Butthole Cancer is another way of referring to anal cancer. Anal cancer is a type of cancer that occurs in the anal canal and the anus. It is a rare disease among the general population, but is very common among gay men. Along with that, infections like HIV and Syphilis are also very common among gay men.

Gay men who don’t have HIV are over 20 times more likely to get anal cancer than the general population. Gay men who DO have HIV are about 100 times more likely to get anal cancer. Rates of anal cancer among gay men have been increasing every year.

This is because gay sex often causes anal fissures or tears. The anus is supposed to remove waste from the body, and having gay sex will eventually cause tears and cuts to the anus. These tears can get infected.
If you're a gay man, then your chances of getting infections and diseases like HIV, AIDS, Syphilis, and anal cancer (or butthole cancer) are quite high.
by Medical School October 18, 2019
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To keep secret or private; possessing information or material that is confidential, only to an individual or select few, and must remain that way.

Popularized in late 2020 Western New York during the COVID-19 pandemic.
I don’t think we should tell Anthony about this. He has never been able to keep it on the butthole with anything. If I know that guy, he will tell everyone and their mother.
by z.e.M.D December 16, 2020
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When you're about to eat out someone's ass, you spread their ass cheeks, exposing yourself to their full moon, and you throw back your head and let out a howl.
You know how Rigby would like to start the night?
By werewolfing a butthole.
by Cyrano515 November 21, 2016
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The act of not wiping your ass after taking a shit either because there is no toilet paper left, or you just chose not to wipe. Leaving your butthole "poopy".
Guy: Shit. Some asshole didn't replace the TP role, guess I'll just have to have a Poopy Butthole
by Lazy Asshole January 21, 2018
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The term ghost butthole refers to the last remaining and moat ashy hit in the bowl of a pipe, bong, chalice, or other kind of smoking pipe and typically refers to marijuana smoking. When a bowl is, "cashed," or no longer contains green, it can be considered a a ghost butthole.
"My friend is truly such a cheapskate... he even saves the ghost buttholes and smokes them later!"
by Elizo Emezeta September 7, 2016
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An involuntary bowel movement usually caused by questionable food choices.
Ugh man, what's that smell?!
I just had a butthole malfunction courtesy of Taco Bell!
by Gleen707 November 28, 2019
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a phrase for using instead of saying
"your mom" or your face"
Jared: hey your shoes are ugly
Jenna: your butthole's ugly.

Jared: your a bitch
Jenna: your buttholes a bitch.

Jared: your hairy.
Jenna: your buttholes hairy.
by averyisacoolkidforreal January 25, 2009
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