Desiganted Ugly Fat Friend. A common acronym used in male cliques. Used to refer to the girl that the "hot chicks" bring along to distract the "Wingman" (every male clique has one, his job is to intercept the DUFF.) so the ycan have the more desirable males of the group.
by TXwolfman817 February 24, 2009
Get the DUFF mug. That place on the human body (particularly the female body) where the body makes contact when sitting-down, i.e. the erogenous area of the butt.
by anonymous March 3, 2023
Get the Duffmug. The shake at the bottom of a bag of drugs, including the seeds and stems in a bag of weed. Commonly used to describe the shake at the bottom of a bag of crystal meth.
by jlthomas110880 November 25, 2020
Get the Duffmug. 
An old Australian Slang term referring to an unplanned pregnancy, first used in 1941 and all the way through to around the 70s. Rarely used now a days.
by Shen Bapri March 23, 2023
Get the Up the duffmug. A person who doesn't do anything productive with their life after high school - no job, no school, just vibes. Can also describe the act of being unproductive or lazy in general. The word originated from the last name Duffey, a kid who famously did absolutely nothing post-graduation.
Used as a noun:
"Don't be a duff — at least try to apply somewhere."
Used as a verb:
"I was just duffin' it all weekend, didn't move off the couch once."
"He's been duffing his life away since senior year."
Used as an adjective:
"That's the most duff thing l've ever seen — unemployed and still
Lplaining."
"Don't be a duff — at least try to apply somewhere."
Used as a verb:
"I was just duffin' it all weekend, didn't move off the couch once."
"He's been duffing his life away since senior year."
Used as an adjective:
"That's the most duff thing l've ever seen — unemployed and still
Lplaining."
by Duffer555 July 21, 2025
Get the Duffmug. You just duffed out!
Man sorry i didn't hear you i was totally duffing out.
I really duffed out on that one
Man sorry i didn't hear you i was totally duffing out.
I really duffed out on that one
by Tazan August 22, 2011
Get the Duffmug.