by Bobz1992 February 7, 2014

A meme come to life, a Fletcher Duff is someone who personifies a number of memes often found on the internet without necessarily directly correlating with just one.
"Oh, that meme reminds me of something - i just can't put my finger on it"
"That must be a Fletcher Duff!"
"That must be a Fletcher Duff!"
by topg43 August 7, 2022

When you have to take a dump right after eating a huge bag of cheetos. Doritos and other orange texturized flavored chips do not count. You should only use the term when the situation is cheetos, not anything else. Spelling doesnt matter as long as its used in the correct context.
After you eat a big bag of cheetos you tell your buddy that youl just be a second, you go the bathroom and realize this might take a while that was a realy big bag of cheetos. For the first time ever youve come to the conclusion you have reached your limit and take a huge dump, the result... an orange duffe.
by od man December 9, 2007

The stuff left on the bottom of your weed bags. All the stems, crystals, and leafs. Often used as a cheaper alternative to buds in baking. Though often mistaken as good, and used in joints and bowls. Known to be sold for as cheap as 30-40 dollars an ounce.
by fitzy_keegs January 13, 2017

(Designated Ugly Fat Friend) A DUFF doesn't always have to be fat or ugly, sometimes a DUFF can be cute, but they're there to make the rest of the group look better and to be the approachable one for anyone seeking inside info.
by YolkyYellow March 30, 2015
