Duff

The brand of beer that Homer drinks in the Simpsons.

Duffman approves this definition

by kunemvu February 23, 2020

Duff

The ugly friend you bring out with you.

Ian is not a Duff

by QuinnIsAJag January 19, 2020

Duff

Dumb, Ugly, Fat, friend

Oh my gosh she is such a duff..

by gamerpeeps500 August 23, 2021

DUFF

Designated Ugly Fat Friend

Bob was a Duff

by prettygangswag12 March 28, 2015

dorcus duff

the local hoodrat or prostitute

guy 1- "did you see that chick on sleeping on the road"
guy 2- "yea must be a dorcus duff"

by jayquan24 September 13, 2020

DUFF

Deluxe Ultra Freaky Friend

man, that girl looks like a DUFF

by jdizzowizzo May 2, 2009

DUFF

The glue to a friendship. She/he will always support there friends no matter what. She can be a pain in the ass but everyone still loves her/him.

wow she is such a duff, i love her.

by ofiherjonfoqe[h November 5, 2018