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ur brother a mother

The biggest roast of all time. Ur mom gay, ur dad lesbian, ur grandmammy tranny, ur grandpap trap, ur sister mister, no u are all inferior.
oofer: ur mom gay
pleb: ur dad lesbian
oofer: no u
pleb: ur grandmammy tranny
oofer: ur sister a mister
pleb: ur grandpap trap
oofer: but ur brother a mother
pleb: *instantly in hell*

ur brother is ur mother

This one is the worst of all the ultimate plot twist, it completely knocks ur mom gay, ur dad lesbian, ur granny tranny, ur granpap a trap, and ur sister is a mister out of the park
Caleb: ur mom gay
Nick: ur brother is ur mother

Ur brother is ur mother

One of the eight most deadly phrases in the world. It has not been muttered since the anciet great wars, not to be used lightly.
Justin: Ur mom gay
Kyle: Ur sister a mister
Justin: That's it... Ur brother is ur mother

All the stars' gravity becomes 10000000000x stronger pulling everything into their reaches. Once the final star has been born the big bang happens again.

ur brother is ur mother

As compared to "ur sister a mister"
It is pretty much the same thing but worse.
John: Ur sister a mister
Rob: Well ur brother is ur mother
John: Oh shit

Ur brother be a mother 

The ultimate, by many forbidden, one line to destroy someones will to live
Ur mom gay
Ur dad lesbian
Ur granny tranny
Ur grandpas asexual
Ur sister a mister
Ur brother be a mother
"Sad opera music plays as screen turns black and white"

Ur brother's A mother 

The ultimate insult. Nothing compares to this. It trumps over ur mom gay, ur dad lesbian, ur granny tranny and makes your grandpap A trap look like "ur stupid".
1: ur mom gay

2: no u

1: well, ur daddy lesbian

2: ur granny tranny

1: noooo, your grandpap A trap

2: you made me do this. (Grows into a giant and raises his hand to the heavens) UR BROTHER'S A MOTHER!!!

(2 brings their hand down and vaporizes 1, then the entire galaxy speeds toward andromeda galaxy at the speed of light, causing a massive black hole that swallows the universe.)