Incredibly sore knees on the morning or day following a night of moderate to heavy drinking. A dull, but intense pain in the entire knee joint; kind of like a headache in your knees. It can be so painful that the sufferer can be almost bed/couch-ridden for most of the day.
"Honey, I can't do the dishes this morning. I can't stand for that long due to a mad case of booze knees."
Bees carry pollen back to the hive in sacks on their legs. It is tempting to explain this phrase as alluding to the concentrated goodness to be found around the bee's knee.
Alison: Swanson, I think you're wonderful.
Swanson: Well, Alison, I think you're the bees knees.