Duff

Designated Ugly Fat Friend is a person that you keep around to be more attractive and popular also known as the D.U.F.F

Two hot girls are sitting with a ugly girl. I feel bad for that Duff.

by Alize Marie September 21, 2017

DUFF

Designated Ugly Fat Freind

Jim: Bob you are my designated ugly fat friend (DUFF)
Bob: I'm not that fat!

by z108108 February 18, 2015

uppa duff

get pregnant after a one night stand

did you hear about her? shes uppa duff

by pierrr April 10, 2021

Duff

Duff is a quiet man when you first meet him yet is incredibly observant and always listening. He takes his time in both thoughts and actions, but in the end is always ready to share the very best of himself. Duff is strong yet gentle, firm yet kind and mushy. If you are lucky enough to have a Duff in your life, then you are guaranteed a funny and generous confidante who will be by your side forever.

You know it's going to be a great night, Duff is coming!

by Duckie1970 December 9, 2023

Duff

The shake at the bottom of a bag of drugs, including the seeds and stems in a bag of weed. Commonly used to describe the shake at the bottom of a bag of crystal meth.

Jeff: Hey, let me get a ball of that fire ice. Dan: All I have left is the duff, bro.

by jlthomas110880 November 25, 2020

Bailey Duff

A weird creature that is ugly and not human

Person 1: the fuck is that
Person 2 : its just a Bailey Duff

by Skkrt skkrt November 3, 2019

DUFF

(Designated Ugly Fat Friend) A DUFF doesn't always have to be fat or ugly, sometimes a DUFF can be cute, but they're there to make the rest of the group look better and to be the approachable one for anyone seeking inside info.

Man 1: "Hey do you know if that hot girl is single?"
Man 2: "I don't know, go ask her DUFF"

by YolkyYellow March 30, 2015