Much like the movie, The Labyrinth, a "bowie knuckle" is an apple-sized lump in the male anatomy protruding in the groinal region. Particularly emphasised by tight spandex pants, or jeans. See also pud.
After taking a poop the average human, chooses to wipe the anus to remove any left over excrement. When in the wiping process if on discovers that fecal matter is left on a finger, he/she has been mud knuckled.
i had some taco bell yesturday, ive been crapping all day, sloppy ones too, i even got mud knuckle it was so bad.