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Duff Neighbor

Duff meaning: Dreadful Ugly Fat Freak of a Neighbor.
A neighbor you dread to see out of their house who is ugly on the inside and out. Morbidly obese, fat, and unfortunately seems to scantily clothed most of the time. A loud ass freak who strives to be obnoxious at all times. They tear around the corner and down your street in their reinforced made for fattys' vehicle like a crazy freak, regardless of any pets or kids that may be in the road. You try to live your life but this Duff neighbor makes it virtually impossible to exist within a 3 block radius without hearing their loud ass bi-polar blabbering. This Duff neighbor likes to do the flubby dance while being hit by the jet stream of a water hose which has been known to cause temporary loss of vision for passer-bys.
I thought they had found the house of their dreams until I saw their Duff Neighbor across the street.

The cat never saw that Duff Neighbor coming.

They don't make fences high enough to completely drown out their Duff Neighbor.
by Sass sha J May 29, 2010
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Duff

noun: The small particles of cannabis, or "shake", in the bottom of your bag of weed.

verb: To remove the shake from finished cannabis buds.
Noun: "Hey check out this pound of Blue Dream I got!"
Looks at bottom of bag, "I don't know man looks like theres an bunch of duff in it.

Verb: "Gotta duff that shit out bro."

"Have these packs been duffed?"
by Little Salt August 7, 2020
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The DUFFE

by Mikey December 1, 2004
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duff

Madi and lily (designated, ugly, fat friend)
Madi and Lily are such duffs!
by YLYILS May 26, 2018
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The duff

Designated ugly fat friends

That one friend group that everbody avoides for obvious reasons
The people that sit near the benches at school are the Duffs of school
by Smonky August 21, 2021
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DUFF

It means "Designated Ugly Fat Friend". They don't have to be any of those, but that doesn't mean they don't have friends more attractive than them. The DUFF is basically the least attractive one in the group.
"She's cute, but her friends are hotter. She must be the DUFF."

"He's the youngest in the team and acts as the Gatekeeper to the rest of the team. He's a DUFF."

"That teacher is being left out from other conversations... He's a teacher DUFF."
by WattpadBlogger September 21, 2017
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Mickey duff

Mickey Duff was a well known boxing promoter whose name is now universally used as rhyming slang for marijuana.

Mickey Duff = Puff
If you want me to roll one up you’ll have to pass me my Mickey Duff.
by Loftier January 23, 2021
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