Duff

The brand of beer that Homer drinks in the Simpsons.

Duffman approves this definition

by kunemvu February 24, 2020

duff

designated ugly fat friend
the more approachable one

you are duff

omg Katey is such a duff in her friend group

by calumhood.com September 07, 2015

Duff

Beer you wish you could have but never will.

I'm craving some duff right now bro.

by lemonberrypie August 04, 2017

duff

dam ugly fucking friend

that girl is a duff

by mariodros September 07, 2017

duff

The stuff left on the bottom of your weed bags. All the stems, crystals, and leafs. Often used as a cheaper alternative to buds in baking. Though often mistaken as good, and used in joints and bowls. Known to be sold for as cheap as 30-40 dollars an ounce.

Hey bro, got any of that duff? I need to make another's batch of weed brownies.

by fitzy_keegs December 21, 2016

Duff

To Duff Out; A momentary lapse in reality shown by a vacant stare into a world of blank.

You just duffed out!

Man sorry i didn't hear you i was totally duffing out.

I really duffed out on that one

by Tazan August 18, 2011

Duff

An alternate name for penis.

"He wants to put his duff where?"

by TeamTripod July 08, 2009