Synonymous with "Affirmative" or "Yes, sir". Originated by the rapper Snoop Doggy Dog. This utterance stands by itself as a full sentence, and is usually not included in other sentences.
"Shall we stroll by the liquor store, and peruse the the tonics, my good sir?"-"fo shizzle my nizzo"
by Zen Psycho September 16, 2003
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G#1: "yo dog, you be illin!"
G#2: "fo shizzle my nizzo!"
by mike September 16, 2003
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ghettoized version of "for sure my nigger" ; when you agree with someone of color
'yo, you wanna go buy some new filas?'

'fo shizzle my nizzle'
by Anonymous September 18, 2003
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translated to: fa sho' my nigga
Aww you coped them new J's fo shizzle my nizzo
by Angeleka September 19, 2003
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