Don't Touch The Poop is a term used amongst followers of Lolcows like Chris Chan, Cyraxx and Daniel Larson as a golden rule of sorts when it comes to their antics online. The act itself is referred to as "Poop Touching" and the people who often engage in Poop Touching are considered Weens
The phrase means to avoid interacting or any other kind of engagement with Lolcows as it usually doesn't result in the reaction you are looking for and more than likely it will also have some sort of negative consequence such as being doxed by more efficient trolls or by the Lolcow themselves.
Person 1: "Yo I'm gonna DM Cyraxx and tell him I'm a girl that thinks he's hot! Won't that be so funny?!"
Person 2: "Thats a stupid fucking idea dude. Don't touch the poop."
Peeing in a man's ass and then immediately putting in a butt plug in his butt forcefully. Then, letting it marinate into a mix of poop and pee, similar to bird poop. After that, you proceed to rip out the butt plug like a ripcord out of a Beyblade and immediately put it into a can and throw it at said bird poop butt person.
Hey, remember when we did the classic 'gay bird poop in a can' to that pledge?