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a diffrent kettle of fish 

a different situation or person to be dealt with

Difference between his asshole and a hole in the ground. 

A metaphor relating to a stupid, ignorance, and educated person that can not distinguish similarities between items or objects.
George is so stupid, he don't know the difference between his asshole and a hole in the ground.

Irreconcilable trumpspective Differences

*see def. trumpspective
The unwillingness, and/or inability, to reconcile profoundly fundamental and essentially divergent truth-claims as to render mutual incompatability.
Can you list 5 things that you DO agree on?
Ummm, Nope. But we can add Irreconcilable trumpspective Differences to the 'DO NOT' list.

it hits differently 

its different than others.
“wow those chips! ya it hits differently

differently abled 

adj. Politically correct 1990s euphemism meaning "disabled". Contrary to what the words may suggest, "differently abled" does NOT mean "having different abilities;" more precisely it means "lacking expected abilities." Since mental disability is generally associated with much more social stigma than physical disability (and hence is ripe for being described by a "sensitive" PC vocabulary), "differently abled" is most frequently encountered in similar contexts as "special". With this in mind, persons of non-retarded status should construe the phrase as a deep insult.
What the teacher thinks: "Goddamn, that was funny! Why do they insist on mainstreaming these plainly retarded kids...they're so distracting to my class..."

What the teacher says: "Class, you should be ashamed of yourselves for laughing when our differently abled peers gave their fine interpretation of Hamlet."
differently abled by Carl Willis January 18, 2005

Vive La Difference 

Vive La Difference is French for long live the difference between the sexes.
In the 54-40 song "Ocean Pearl" they include the phrase Vive La Difference.

The line "I'm gonna put the Vive back in La Difference yea" referring to the difference between him and his "Ocean Pearl".