DOI Share definition Flag Driving Over the Influence (DOI). If you drive over the influence, it means you are driving not intoxicated by alcohol or drugs. Guy #1: Did you get a DUI? Guy #2: No, I got a DOI, so I’m not getting arrested. DOI by anonymous July 16, 2022 0 0 Get merch Get the DOI mug. Buy Now — $32.95 See more merch