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Oh my God! 

An appeal to a deity.

Or just something said as an exclamation point or as a swear word when angry.
What Moses was taking about when he said thou shall not take the name of the Lord your god in vain.
Oh my God! I hate this freaking class!
Related Words

Is God real? 

No.
Nick: "Hey Alex, is God real?"
Alex: "No."
Is God real? by laertonsidog May 28, 2016
A female master of all things pie-related, whether it be the creation of, or consumption of pies.
Ian is an amazing Pie god
Pie God by WhippingBoy December 11, 2003

Their Eyes Were Watching God 

An excellent novel written by Zora Neale Hurston in 1937. The book details the life of Janie Crawford , a Southern black woman, and her search to find her voice and her one true love. This novel was popularized partly by it's inclusion as required reading within some high school English classes, Oprah Winfrey’s book club, and the fact that it is very original and enthralling, giving the reader a new sense of what the world was like in the 1930’s through the eyes of a strong-willed black woman.
Student #1: Is Mrs. Essigmann making your class read 'Their Eyes Were Watching God', too?

Student #2: Shut the fuck up.

holy mother of god 

When you witness a naked Vietnamese man in a shower with his niece biting off his pubic hairs.
Holy mother of god, I think those Tung Kee nips stole my daughter!
holy mother of god by ekoshyun June 30, 2003

This school food be disgustin disgustin not bussin bussin on god no kizzy pls help me i'm being held hostage in chin- 

When This school food be disgustin disgustin not bussin bussin on god no kizzy pls help me i'm being held hostage in chin-
MOM PLEASE HELP ME This school food be disgustin disgustin not bussin bussin on god no kizzy pls help me i'm being held hostage in chin-