Shapoopi Share definition Flag A shapoopi is a girl that's hard to get. The word was made up by Seth MacFarlane and used in the hit T.V. show Family Guy. Shapoopie! Shapoopie! The girl who's hard to get.Wow, that girl's such a shapoopi. Shapoopi by JamesDrennan08 May 15, 2009 0 0 Get merch Get the Shapoopi mug. Buy Now — $32.95 See more merch