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Lame nigga syndrome 

When a women has been in close contract with lame niggas for too long she begins to become sick physically. This is know as lame not nigga syndrome. Side effects may include light headedness, stomach ache, mood swings, migraines, fatigue, body aches (etc)
“I was hanging out with those dudes from the bar this weekend and now I’m feeling sick, I think I’m suffering from lame nigga syndrome”.

“Emma can’t come out tonight she said she is not feeling well after hanging with frat boys too long, she thinks she has lame nigga syndrome.

Thick booty Nigga syndrome 

A syndrome when a male has an ass so so fat it gets them to a state where he shows insecurity, upset, annoyed, angry, and quiet
Friend A: Aye bro do you struggle to find pants?
Friend B: Bro stop asking me that your chatting, your pissing me off!

Friend: (That’s that thick booty nigga syndrome...)

Slow Nigga Syndrome 

Usually involving one member in a group. When something is said or done and there is that ONE friend in the group who is the last one to get it. Usually the last one to get it is the same person every single time. Does not exclude one race this syndrome is contagious through all races.
Friend A " 9+10 is 21" *everybody laughs* Friend B" But bro 9+10 isn't 21 it's 19 " Friend A "yo that's the joke remember that vine" Friend B "OH RIGHT" Friend B suffers from Slow Nigga Syndrome.

one nigga syndrome 

A pathetic condition/policy where there's only room for one Black person to shine in (at least the mainstream of) a given industry or scene, even when there are many other talented and worthy Black people to give work or accolades to. Unfortunately usually those other Black persons (as well as Asian, Latino, etc.) are snubbed or overlooked in favor of the anointed Black talent and/or a whole bunch of mediocre whites.

Oftentimes even that particular one Black will see to it no one else benefits from the perks they get, out of feeling those others are a threat to take their position.

Not to necessarily be related to affirmative action, though it kinda can be. And while not necessarily tokenism, one nigga syndrome is also in effect when whites will bring aboard one Black person into the group and cap it there so that in case he gets out of hand, he won't have backup when they collude against him.
Tyra Banks tended to be a victim of one nigga syndrome when Naomi Campbell was the go-to Black supermodel at the time.

One nigga syndrome was in effect on all but two seasons of The Real World. Notice how the token Black also tends to be gay.
one nigga syndrome by Kuahmel December 20, 2009

Real Nigga Syndrome 

A state at which you have became so much of a real nigga that you can not die
Guy 1: Dude did you find out?
Guy 2: What man.
Guy 1: I have Real Nigga Syndrome
Guy 2: Ahh man that sucks, no dying and shit

Third nigga syndrome 

Third nigga syndrome is a side effect of several varieties of ganja, but is almost guaranteed if one smokes a large amount of a purple strain.

Third nigga syndrome is a mental thought loop where one gets too stoned and believes there is another nigga with them, and for some reason, it only really happens when you’re high as eagle with one of your niggas. You may see the third nigga out of the corner of your eye, or just sense the third nigga’s presence nearby. In groups larger than two or whilst smoking solo the extra imaginary nigga is rarely sensed.
“Yoooooo where’s the other buhl with us?”

‘Oh shit...where did that nigga go?’
“Yo there’s definitely a third nigga with us”
‘I know, right?’

“Yo we got third nigga syndrome.”
‘Oh big facts.’

Big Nigga Syndrome

Big Nigga Syndrome is a condition of big body, low intelligence (intelgence), & skeevy and/or hinky behavioral tendencies. Those afflicted with the Syndrome tend to use their size to inflict their will or intimidate others.
I didn't mess with him. He has Big Nigga Syndrome.