1. The moment when a mind-altering substance begins to act in one's system.

2. The onset of the effect(s) of a mind-altering substance after its inhalation, ingestion or injection.
Dude, you'll definitely take-off before you finish smoking that giant blunt.
by m-fun December 15, 2019
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Typically used on the east coast from Georgia down to Ohio. Taking off essentially means that you have just taken several hits of a joint. Take off is the act of getting stoned.
Person 1: “hey bro do you wanna take off right now?”

Person 2: “let’s do it man, let me grind these bud and roll it bro!”
by Twotenor December 21, 2021
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When you haven’t had a bowel movement in 3 days and you know it’s gonna be old and slow. After 45 minutes it finally shows up and smells like Geritol and Ben-Gay. You’re left sweating and breathing hard and your butt hurts like you were in the Navy for 8 years
My stomach is cramping, feels like I got to take a J.R.
by Highrail Brian May 28, 2021
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When one has absorbed copious amounts of Mexican food and does not realize they need to poop. They then believe they are going to release the most satisfying fart in the history of time, but instead drop of a mountain of shit into their pants. They then make their fiance wash their tainted pants. Also used as a general term for basic bowel movement.
Hey it smells like tacos in here
Yeah I'm about to Take A Clay, fire up that washing machine
by Honky Actual May 20, 2016
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An aggressive statement yelled or shouted to encourage the completion of a goal or mission
by Martey January 10, 2020
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