A best friend that you can call sis-sis instead of sis. Female version of brobro. Guys can have a best friend that is a girl that you can call sis-sis and nothing is going on or no one is going out.. Normally if you are best friends you can treat her like a real sister. You can love her like a real sister say I love you like you say to a real sister. Basically best friends.
Jason: Wow Chelsea, we have been friends for years now and I proud to call you my sis-sis.
Chelsea: Thanks Jason! Can I call you brobro?
Jason: Sure sis-sis.
Chelsea: Love ya brobro.
Jason: Love ya sis-sis.
Chelsea: Thanks Jason! Can I call you brobro?
Jason: Sure sis-sis.
Chelsea: Love ya brobro.
Jason: Love ya sis-sis.
by Thekidwhoisakidthatgoestomps January 25, 2011

a philosopher of sorts. looks into a mirror and will see many reflections.
resembles a chilly philly dip; sweet and TANGY.
resembles a chilly philly dip; sweet and TANGY.
by lawren August 2, 2006

by will bitten December 21, 2016

Susan: “how was your weekend?”
Janet: “sis...”
Susan: “omg sis what’s the tea sis—spill!”
Janet: “sis!”
Susan “sis”
—and so on and so forth until Antichrist comes and the world is over
Janet: “sis...”
Susan: “omg sis what’s the tea sis—spill!”
Janet: “sis!”
Susan “sis”
—and so on and so forth until Antichrist comes and the world is over
by Theworldisflat.edu August 3, 2018

by One Six One February 6, 2008

Abbreviation for: "Sisters, In, Spirit". Your Best Friend or Bae. Usually used to refer to someone really close to you, someone you spend a lot of time with, like your sister.
by ChocolateWafflez April 15, 2015
