New York slang. Abbreviation of "On The Ave/Avenue". New York City has many streets and popular Avenues locals commonly use to quickly reference relative location.
"Yo my mans, how far you from the spot?""I'm OTA like 2 blocks away"
Basically means: "Want another one?"
Professional Counter Strikeplayer LUCAS1 screams "QUE OTA" after delivering one headshot with the Desert Eagle pistol in the game, now it has become common to scream QUE OTA after headshoting someone with a Desert Eagle.
Counter Strikeplayer: *headshots someone with a Desert Eagle* QUE OTA? Hey man you saw that?
Friend: Man that was a sick QUE OTA!