OSU 

There are three major OSU's out there.

OSU or tOSU = The Ohio State University
oSu = Oklahoma State University
osu = Oregon State University

The lesson learned from this is don't go to any of these OSUs.

OSU by kevin4cardinals January 4, 2005

OSU 

On stage urination. When someone who is on stage performing decides to urinate right there.

I didn't know Fergie liked OSU

OSU by Amy Ger December 29, 2007

osu 

Oh Shut UP

osu by arran October 14, 2003

osu 

OSU--Oklahoma State University, located in Stoolwater Oklahoma. Largest community college for vets. Laughing stock of the Big 12.

OSU- AKA: "Shit-hole U". "shit kickers Univ".

"Man, I feel bad for those people that have to live in Stoolwater, next to OSU, I hear it smells like shit"

osu by boomersooner November 7, 2006

Osu 

Mostly use in Nigeria among the fraudsters to describe a victims who got into their traps

I don catch Osu.

Osu by anonymous December 29, 2021

osu 

bad

osu is horrible

osu by qsdfghtgery4lg4k5rgt February 3, 2022

osu 

That anime weeb game 727 pp farming

osu is addictive

osu by anonymous May 13, 2022