mono 

a sickness usually spread by kissing, but NOT always, and it is when you have an overlarged liver. you shouldnt do physical activity, and its contagious.

i cant have sex, i have mono.

mono by kelly margaret April 27, 2006

Mono 

The combination of various styles of music to create a mental flow with constant attraction to the spirit created by god himself
Random combinations of hip hop rhythms paired with jazz, blues, gospel, trance, techno, rock, r&b to create a new sound that can make your pants jizz.

I can’t wait for mono oh my god

Mono by Samhoseok October 22, 2018

Mono 

To describe someone

Someone is a Mono when...
They talks to themselves
They drinks a coffee too fast
They kin a lot of random characters
A Mono usually gives off extremely British vibes and gets headaches on Mondays

*aggressively gets a headache*
you're pulling a Mono again

Mono by providedbyMono December 21, 2020

Mono 

Mononucleosis (Mono) : Giving a person STD mouth to mouth or saliva.

" im going to give you hardcore mono"

"me giving you mono."

Mono by drrapper May 18, 2023

Mono 

when a user of pokemon is challenged to beat the entire game with one type of pokemon

Guy 1: Hey dude i challenge you to do a Mono water on leafgreen
Guy 2: Ok i will record it and put it on youtube

This means Guy 2 has to beat all of leaf green with water types

Mono by Thomas Berkun October 7, 2008

Mono 

Mono is an amazing person who cute,and friendly with everyone and the best fucking monkey ever and better then you every way possible.

I'm a Mono

Mono by MiniMonoMan🐵 March 12, 2017

Mono 

To be angry.
(because when you're angry you frown and get a mono-brow)

He was getting mono... etc

Mono by Charlotte Lord February 24, 2009