An accusation towards someone who is suspected of interfering in your business in a secretive or deceitful manner.
You think your friend might be seeing your girlfriend and say "Have you been putting butter in my honey?" OR: You suspect that someone has been talking about you behind your back. OR: You think someone used a dirty butter knife in your honey jar.
A parody of Gangsta speak, or "Ebonics", wherein people call each other Homie. Taken from the game version of "White men can't jump", which features some of the worst Ebonics in history.
The original source for this word direct quote from seanbaby.com's review of the game in the 20 worst games in history: "BANGIN' UP HIGH THE HANDLE HOMEY BEEF!"