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Old Milwaukee Syndrome 

A description of something or someone that when totally optimized is still complete crap. The expression originates from the advertising campaign for Old Milwaukee Beer: despite the beer being only barely better that drinking pond water, its slogan was "It just doesn't get any better than this!"
John:"What's up with your front yard?"
Ben: "I know, I've spent the last three weekends weeding, fertilizing, mowing, trimming . . . and it still looks like a dirt lot."
John: "Another case of Old Milwaukee Syndrome, it just doesn't get any better than this."
Old Milwaukee Syndrome by olsongt October 21, 2009
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platinum pussy syndrome 

This serious mental affliction occurs when a female is under the false impression that her vagina ALONE has powers that surpass all other women on earth in the ability to keep a man. Also known as PPS
Most groupies & gold diggers suffer from platinum pussy syndrome, till those divorce papers roll through

Scrappy Doo Syndrome

When the makers of a television show decide that adding a cute kid to the cast will make the ratings of the show go up. This normally is not the case. Comes from the fact that Scrappy Doo supposedly made to entire Scooby Doo cartoon get cancelled
Examples:
The Cosby Show- Olivia
Smurfs- The Smurflings
Scooby Doo- Scrappy Doo
The Brady Bunch- Cousin Oliver

Cage Syndrome 

(n.) The inability to turn down theatrical roles, even if they could indeed ruin one's career. Brought about by such actors as Samuel L. Jackson (appearing in Snakes on a Plane for Christ's sake), and most importantly Nicholas Cage, for the syndrome is founded upon his decisions acutely, the actors continue disappoint many with their unwarranted actions.
Damn, Nicholas Cage has the worst case of cage syndrome ever. He fucking agreed to Knowing and Ghost Rider of all god damn movies in this world.
Cage Syndrome by demosthenes29 August 22, 2009

camel toe syndrome 

The slang term for the sometimes cronic condition affecting the genital region specifically in women and officially listed in medical references as "dromedary tarsal phalanxosis"
...the patient in question, having a 47 inch girth and a substantially prominent mons-pubis, had somehow managed to force herself into a pair of size 2 capri pants resulting in the onset of lateral pelvic running-boardititis accompanied by a terminal case of dromedary tarsal phalanxosis, otherwise known as "camel toe syndrome".
camel toe syndrome by A. Mike. J. August 17, 2006

Status Update Syndrome 

People who update their status too much on Facebook, Hogging up the news feed and talking insignificant rubbish, or pretty much revealing their personal lives bit by bit just to get attention.
" I woke up" 7.00am

"Im brushing my teeth, LOL" 7.01am

"Thinking should I have semi skimmed or full fat" 7.03am

"Since I got no reply, I will use full fat LMAO" 7.04am

"Why isnt nobody responding?" 7.05am

"I think I got Status Update Syndrome :'("

Smosh Syndrome 

Smosh Syndrome is when you watch a bunch of Smosh videos and try to act like Anthony and Ian.
Me:"What the FIRETRUCK!" "Cannon Penis!" "Cute Furry Kittens puking all over the place.."
John: "What's wrong with you?"
Me:"I watched a bunch of Smosh videos.."
John:"Oh, you have Smosh Syndrome."