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People with Trans Derangement Syndrome have been trained to have an extreme adverse Pavlovian response to anything suggesting 'trans'.

The mere utterance of the word trans or they/them bypasses the higher-thinking circuitry of the brain and triggers the primitive rage centres to go off.
Person 1: “is JK Rowling ok? They seem mentally unwell”

Person 2: “no, seems like they have a serious case of trans derangement syndrome (TDS)”
by Robert_G_ September 4, 2025
mugGet the Trans Derangement Syndrome (TDS)mug.

TDS

TDS is an OG DBZFS clan that has recently moved to a multi game clan. It consists of Xbox,PS4 and PC Players
Have you ever heard of TDS ??

Yeah TDS on top BTW
by Tremmyyy August 22, 2022
mugGet the TDSmug.

TDS

Trump Derangement Syndrome or Tower Defense- *ahem* Delay Simulator
robloxian: "Yo, wanna play TDS?"
robloxian2: "Play what?"
robloxian: "TDS, Tower Defense Simulator."
robloxian2: "Oh. Yeah, sure."
by me the when May 26, 2021
mugGet the TDSmug.
This is the actual comprehensive definition of TDS / Trump Derangement Syndrome.
(All the other definitions appear to be people just throwing mud at each other.)

TDS is a blend of psychological phenomena related to bias, prejudice, and cognitive distortion. It was coined Trump Derangement Syndrome due to the extreme hatred of Donald Trump by the managerial class/establishment and the NPCs and/or low information voters that follow their command.

TL:DR
In simple terms, this phenomenon occurs when someone is so biased that they interpret everything from a person or thing they dislike in the most negative way possible. For instance, if you wave hello and say good morning, they might think your friendly gestures are actually hidden insults or ominous threats. It's a form of "persecutory paranoia" and/or "hostile attribution bias".

Projection issues for those suffering from TDS:
People with TDS often see any neutral or positive stance as covert support for the person they hate, assuming that those who don't share their negative view are hidden supporters. This reinforces their paranoia and resistance to differing viewpoints.

These factors create a syndrome where hatred or bias blinds people to objective information and critical thinking, leading them to embrace propaganda, avoid independent analysis, and cling to their negative views.
Examples of TDS, Trump Derangement Syndrome:

Simple Example: Sarah, who dislikes John, interprets his friendly “Good morning” and smile as a disguised insult. She believes he’s mocking her, even though his intentions are completely harmless.

Real Life Example: Destiny (YouTube) is a prime example of someone exhibiting extreme TDS (Trump Derangement Syndrome). (Also see: The Rationalization Hamster)
by ApplesPotatoGardner August 20, 2024
mugGet the TDS, Trump Derangement Syndromemug.

TD

Typically Develoving people, aka Neurotypicals, not Autistic.
TD children are much less likely to get stressed out, unlike children with Asperger's Syndrome.
by ronieitan December 20, 2016
mugGet the TDmug.

TDS

(T)rump (D)ick (S)yndrome is a medical condition where an uncircumcised penis is so small that it has the appearance of a mushroom.
I was really into a guy, but he had TDS and I have an allergy to mushrooms.
by DrunkenToothlessRedneck September 4, 2025
mugGet the TDSmug.

TDS

1) Trump Derangement Syndrome

2) (...) Dependency (...)
3) (...) Despondency (...)
TDS takes one of 3 forms and I use (...) instead of repeating certain repetitive words. Can you guess which words I replaced with (...)?
by Sexydimma June 5, 2021
mugGet the TDSmug.

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