by Leonai_art February 21, 2020

When one becomes tired from interacting with to many people, or from to having a conversation for too long. Especially common in with introverts
“After dealing with all of those customers I feel people fatigue coming on”
Or
“Hey, why did you leave the party?”
“Oh, I just got people fatigued.”
Or
“Hey, why did you leave the party?”
“Oh, I just got people fatigued.”
by TyJaxx August 20, 2022

It's a made up fatigue where your sanity is being destroyed from repetitively texturing Splatoon models for two days.
by okmrsavage September 17, 2022

The exhaustion you feel from having to speak to your neighbors every time you go outside. The moment you step outdoors, they want to chat when you want to chill out or work in the yard. neighbors, frontyard, backyard, annoying neighbors, neighbors from hell, next-door neighbors, neighborhood, home, picket fence, fence
Every Saturday, I never get any work done because 4 or 5 of my neighbors come over to talk about their families, kids and jobs. I've got serious neighbor fatigue.
by joecoolthefool July 8, 2017

Felling tired or fatigued by a common internet joke, saying, photo, or gif. (Meme.) Someone experiencing Viral Fatigue may feel like a meme is "beating a dead horse." The meme may be old, common, and overused, resulting in it not being humorous.
by racergamer February 22, 2015

Skype fatigue occurs when one grows so weary from the lack of physical contact in a long distance relationship that one begins to resent Skype as though it were responsible.
On her 100th day apart from Darren, Amy developed a case of Skype fatigue and spent the entire day in bed, sobbing, completely unable to even look at her laptop.
by PrairiePaloma November 5, 2012

Mettle means your ability to cope and persevere, so when your coping skills are exhausted, this is known as mettle fatigue.
The COVID-19 pandemic has caused near universal mettle fatigue.
Mettle fatigue caused a catastrophic failure to follow social distancing guidelines and resulted in a super spreader event with copious amounts of antisocial nearing .
Mettle fatigue caused a catastrophic failure to follow social distancing guidelines and resulted in a super spreader event with copious amounts of antisocial nearing .
by NeologianPJG February 24, 2021
