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The Big O 

Not to be confused wih the suggestive word "Big O", this is a show where Roger Smith does random shit accompanied by a beautiful android. However every character is probably aware of the fourth wall and try too hard not to break it.
John: Did you see The Big O?
Fanny: It's only a decade-old anime.
John: But it's one of the mindfucking show I've ever seen.
The Big O by Leviaiz December 30, 2021
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The Big "O" 

"The Big O" with a woman has been elusive for Pete for many years.

The Big "O" 

Roy Orbison - One of rock music's truly legendary figures.
Ooby Dooby: "you wiggle and you shake like a big rattlesnake."
The Big "O" by Triffid June 24, 2005

The Big C.O.

If I gained 300 pounds and learned fortran I would be The Big C.O.
The Big C.O. by John French July 8, 2004

the big four'o 

I would think that's a phrase used when someone turns forty (40) years old
Congratulations with the big four'O , He /she celebrated the big four'O

THE BIG N.O.B 

THE BIG N.O.B Is a place in San Jose that is ran by three jocking kids that went to MMS a school near THE BIG N.O.B
THE BIG N.O.B was run by those old geezers Johann, Sami, and Aashish.

The Big Oof 

The Big Oof by PopeGod March 14, 2018