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when you are making a joke not funny anymore like when everyone is laughing and having a good time and someone out of nowhere just gets naked, they say kills.
OH KILLS.
man: hey hows it going
dude: fine how are you?
man:nice weather today is it?
dude: ummmm i like the ground
man: OH Kills!
Kills! by ScabsInMyUterus October 18, 2008

Kills Me 

Kills Me can be used in describing a thing, person, object or anything basically. It means that a thing has a trait that causes an emotionally reaction in the person viewing the thing.

Variations are;
Kill me
Killed me

The well known novel, The Catcher in the Rye (J.D. Salinger) features the character Holden Caulfield who frequently uses the phrase when reacting to phonies.
That girl is so good looking she kills me.

That movie was so bad it killed me.
Kills Me by Holden M. Caulfield December 30, 2005

kills it 

When something is, or is done extremely well, or when a man/woman is very attractive.
that chocolate cake kills it

(about a hot woman) she kills it
kills it by james4658 January 23, 2011

Kills The Enemy

Close-knit family in South Dakota who are kick ass!!
Have you met the Kills The Enemy's? They totally rock!
Kills The Enemy by Alive And January 20, 2009

*kills a puppy* 

used in threads, like on facebook or myspace, to show that someone has just asked a question which has been asked a million times before and to which the answer is obvious.
Greg: Hey, what's up with the whole puppy killing thing?

Jordan: *kills a puppy*
*kills a puppy* by ribbitt January 11, 2008

kills people

A adjective used to describe something very intensely cool or fun.
Guy #1 "Dude, this song fuckin' kills people"
Guy #2 "Yeah, it is pretty fuckin' good."
kills people by MattyDPimp August 5, 2007