East coast slang for an annoying pest who no matter how much you try and get rid of, persists and continues to annoy. Usually every "clique" or friend group has one and although they put on an act while around the "gu"; they ignore him/her at all costs and joke about how much of a "gu" that person is. In addition to having no friends, the "gu" is the epitimy of grossness and therefore has zerogame with the ladies.
Man did you seethat guy walking with that group of people. Ya he was such a gu.